BEYOND APRAXIA: NEUROCOGNITIVE PROFILE AND IMAGING BIOMARKERS IN CORTICOBASAL SYNDROME
Abstract
Introduction. Corticobasal syndrome (CBS) is a neurodegenerative disorder with distinctive motor and cognitive alterations. Objective. To synthesize the scientific literature on CBS, its neuroimaging report and neuropsychological profile. Methods. It was structured as a subject review, where a search of scientific articles in indexed journals was carried out. Results. It is highlighted that cognitive dysfunction is characterized by apraxias, aphasias and sometimes executive dysfunction, it is also found that motor symptoms tend to intensify with the progression of the disease. Regarding neuroimaging, the main atrophy and hypometabolism evidenced is presented in frontal, temporal, parietal and striate nuclei. Discussion. These results offer a comprehensive framework for understanding the development of CBS, providing a reference point for differential diagnosis, due to the heterogeneity of the underlying neuropathological diseases, being Corticobasal Dementia, the most common, but not the only one. Conclusions. A treatment is evidenced, with pharmacological and non-pharmacological is mainly symptomatic that alleviate the impact on the daily life of patients with CBS, but of which future research is needed.
Keywords: Corticobasal syndrome; apraxias; agnosia; language; neuropsychology; neuroimaging.
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Copyright (c) 2026 Mariana Vásquez Builes , Valentina Zuluaga Aristizábal , Ricardo Montoya-Monsalve
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